781 Preclinical assessment of MicroMatrix® + Cytal® and Integra® DRT in a porcine third-degree burn model

Third-degree burn wounds can cause devastating loss of functionality for patients. As such, platform technologies that allow effective wound management are needed. The purpose this study is to describe the use MatriStem™ urinary bladder matrix (UBM)-based products (MicroMatrix® + Cytal®) (MM+C) and a collagen glycosaminoglycan (GAG) product (Integra® Dermal Regeneration Template (DRT)) (DRT) in porcine third-degree model. Full-thickness burns were created on dorsal skin, debrided using an excisional model, then treated with MM+C or DRT. Importantly, treatment either DRT, resulted extracellular composition cellular organization similar healthy skin. promoted rapid closure neo-epithelialization, while DRT seemed superior promoting pro-regenerative dermal bed. Histological analysis demonstrated complete epidermal at various levels maturation presented mature, thick, organized bundles all wounds. appeared have more histological resemblance native tissue compared untreated control. faster epithelialization Multi-factor healing both had favorable based metrics contraction, epithelialization, rate. Taken together, closure. synergistic benefits (promoting bed) neo-epithelialization) could be explored combination device facilitate full-thickness